Pharmaceutical

Gilson instruments are ideally suited for the pharmaceutical, biopharmaceutical, and biotechnology industries, and are used early in the drug development process. New drug candidates are synthesized or extracted from a natural source and need to be purified prior to further analysis or scale up. Gilson provides advanced systems for drug purification including automated liquid handlers, preparative HPLC systems, and individual system components, including pumps, valves, detectors, and fraction collectors – all under the control of a software that is specifically designed for preparative chromatography.

Product Categories

• Liquid Chromatography Systems
• Liquid Handlers & Injectors
• Pumps
• Detectors
• Fraction Collectors

Pharmaceutical Applications

Click on the application note of interest to open and download.

• Selecting the Appropriate Laboratory Equipment: The Coomassie (Bradford) Protein Assay Performed Manually using Gilson PIPETMAN® M Multichannel, PIPETMAN L, and Automated using GX-271 ASPEC™ and GX-241 Liquid Handler - June 2012
• An Undergraduate's Approach to Method Development: Chromatography Lessons Learned through Experimentation - June 2012
• Manual Automation of Rapid N-Glycan Sample Preparation - Reliable Results From Error Free Sample Tracking and Accurate Pipetting - June 2011
• Purification and Analysis of Bioactive Extracts from Marine Yeast with the Gilson Semi-Micro 2D HPLC System - May 2012
• Automated Separation of Crude Extracts from Natural Products into Fractions for Primary High Throughput Screening - May 2012
• Natural Product Purification of Lycopene and B-Carotene Using Flash Column Sample Clean-up Prior to High Pressure Normal Phase Chromatography on the Gilson PLC 2020 - May 2012
• A Quick Study - Comparison of Chromatography Normal Phase vs. Flash on the Gilson PLC 2020 - January 2012
• Improving Laboratory Efficiency & Flexibility with Integrating Automated Sample Preparation Systems - The Impact of the Gilson GX-281 Dual Z-Arm Weighing Station - January 2012
• Automated Solid Phase Extraction (SPE) of Benzodiazepines from Urine using the Gilson GX-274 ASPEC™ - October 2011
• A practical User Guide for the Determination of Optimal Purification Gradients for the Gilson PLC 2020 - October 2011
• Automated Determination of VMA, HVA, 5-HIAA in Urine Using the Gilson GX-274 and Gilson ASPEC™ XL - September 2011
• Rapid Isolation of Geraniin from Nephelium Lappaceum Rind Waste Using the Gilson GX-281 Preparative HPLC Purification System - September 2011
• Identifying and Collecting Weak UV Absorbance and Low Level Peaks of Interest From a Complex Mixture Using Conditional Logic Purification on Mass and UV Signals - September 2011
• Optimizing the Purification of a Satandard Chiral Compound Utilizing a Benchtop, Multi-purpose, Semi-Preparative to Preparative HPLC System - July 2011
• Automated Solid Phase Extraction of Allantoin From Cosmetics and Topical Pharmaceuticals Prior to Analysis by HPLC - December 2010
• Processing Human Serum for Rapid and Reproducible N-Glycan Mass Profiling – August 2010
• FTLC Fraction Trapping Liquid Chromatography – 2009
• Automated Fractionation System that Increases Recovery and Optimizes Precision of Solid Phase Extraction Methodology – 2007
• A Novel approach to GX-281 Semi-Preparative System Purification of Natural Compounds Using Isolation Gradients - 2006
• Systematic Look at the Affects of Various Solvents, Injection Techniques and Sample Amounts on Preparative HPLC Columns – 2005
• A Totally Automated Solution for Normal and RP Preparative HPLC with Analytical Purification Determination: cLC – 2005
• A Compact Automated Liquid Handler for Microbatch Protein Crystallography – 2004
• A Multipurpose Preparative System for the Detection and Collection of Active and Non-active UV/VIS Compounds – 2004
• An Automated SPE Procedure and Analysis for the Extraction of Chlorpromazine and Thiorizidine from Plasma – 2004
• Fast PCLC: A Widely Application Technique for Laboratory Scale Preparative Separations – 2004
• An Automated SPE Procedure and Analysis for the Determination of Ibuprofen and Ketoprofen from Plasma – 2003
• The Ephedra Story: An Automated SPE Procedure and Analysis for the Determination of Ephedra and Ephedra-like Compounds in Foods and Dietary Supplements – 2003
• Automated Preparation of MALDI-TOF Plates via a Spring-Loaded Probe - 2003