Forensic toxicology is part of the science of pharmacology, and is defined as the analysis of biological samples for the presence of drugs and metabolites or biomarkers. This also includes studying the adverse effects of drugs and chemicals on living organisms.
Accurate and rapid detection of prohibited substances present in complex biological matrices is crucial for testing laboratories. Robust instrumentation, a flexible software interface that meets the needs of the scientist, reproducible methods, and traceability are all needed in regulated environments.
Tetrahydrocannabinol (THC) is the principal active component in marijuana. It is rapidly absorbed by inhalation and the gastrointestinal tract. Being stored in the fat tissue of the body, it is released over a long period of time. This application note discusses a simple and effective automated solid phase extraction method using the ASPEC 274 prior to sample analysis via LC/MS-MS for THC and its major metabolites in whole blood.
Δ9-tetrahydrocannabinol and its metabolites are essential for drug testing. GC/MS is often used for quantification of Δ9-tetrahydrocannabinol; however, it is time-consuming. Rapid methods that maintain the sensitivity and selectivity of GC/MS are desirable - learn more in this application note.
This ASPEC® system for positive pressure solid phase extraction (SPE) maximizes throughput by processing up to four samples in parallel. With its small footprint and multiple probes, it is the ideal choice for high-throughput SPE automation on 1, 3, or 6 mL cartridges. Combined with ASPEC SPE Cartridges, it generates reproducible and efficient sample cleanup for clinical, forensic, doping, food, and environmental testing labs.
This compact ASPEC® system combines positive pressure solid phase extraction (SPE) with precise liquid handling for reliable automated SPE applications. Its minimized footprint makes it the ideal choice for basic SPE automation when bench space or throughput is limited. The dual syringe pump option allows for automated internal standard addition. Combined with ASPEC SPE Cartridges, the system generates reproducible sample cleanup for clinical, forensic, doping, food, and environmental research labs.
This ASPEC 271 System provides the ultimate versatility by combining flexible, positive pressure solid phase extraction (SPE), precise liquid handling, large bed capacity, and on-line integration with liquid chromatography (LC) systems. With its large cartridge capacity and small footprint, it enables unattended processing of a high number of samples per day for any SPE application, even those requiring multiple cartridge extractions.
With a uniform and consistent flow rate, the ASPEC Positive Pressure Manifold improves solid phase extraction (SPE) reproducibility and recovery, even with high viscosity samples. The manifold offers better control among samples and between runs than traditional vacuum manifolds, providing greater confidence in your data. It’s easy to set up and use, so you can start immediately.
The cost-effective, pre-capped ASPEC® Solid Phase Extraction (SPE) cartridges tackle most separation challenges and are ready to use on any ASPEC System. Each phase allows low solvent consumption and reliable analysis with reproducible separation, high loading capacity, and accurate elution properties.
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