Automation of Post-Purification Analysis Sample Prep

Following successful purification of small molecule drug candidates, it is necessary to pool the fractions, dry down those pooled fractions, and then prepare samples for analysis from this dried solid. Usually, the analysis of choice is a combination of analytical LCMS and NMR. To do this, it is necessary to re-dissolve the dried solid in a known quantity of a suitable solvent and then transfer small aliquots from this sample into the appropriate analysis tubes and vials.

This technical note shows how the use of a suitable Gilson liquid handler and TRILUTION® LH Software makes it is possible to automate this process. Automating this process reduces manual handling errors and provides traceability where previously there was none. Additionally, it also frees up laboratory staff time.


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