Targeted Purification of an Antimalarial Compound from Artemisia Annua L. Extract

Artemisinin is a sesquiterpene lactone obtained from sweet wormwood, Artemisia Annua L. The extract of the leaves of Artemisia Annua L. is used in ancient Chinese herbal therapy for malarial fevers. Artemisinin has been identified as an active antimalarial compound. In this application note, the use of CPC coupled with a preparative liquid chromatography system equipped with UV-DAD and mass spectrometry (MS) detectors, illustrates the success of such technologies to isolate active compounds from complex mixtures.